[μάτην] accusative case of a derivative of the base of G3145 (through the idea of tentative manipulation, i.e. unsuccessful search, or else of punishment); folly, i.e. (adverbially) to no purpose
Usages throughout the bible
Matthew 15:9
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But in vain G3155 they do worship me, teaching for doctrines the commandments of men.
Mark 7:7
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Howbeit in vain G3155 do they worship me, teaching for doctrines the commandments of men.